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Author

Bruce A. Berkowitz

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Open access Oct 2026

The A53T Parkinson’s Disease Mouse Model Shows Abnormal Outer Retinal OCT Metabolic Biomarker Patterns

Purpose The purpose of this study was to test for abnormal optical coherence tomography (OCT) metabolic biomarker patterns in the A53T Parkinson's disease model, which accumulates α-synuclein in photoreceptor inner segments before overt motor symptoms. Methods Four-to-6-month-old transgenic A53T homozygous mice and B6C...

Ehimenmen S. Ataman, C. T. O. Nguyen, D. I. Finkelstein et al. · 0 citations
Open access Sep 2026

OCT Biomarker Testing for Early Dysregulated Photoreceptor Metabolism in Dark-Reared Pde6brd10 Mice

Purpose The purpose of this study was to noninvasively test the hypothesis that dysregulated photoreceptor metabolism occurs with early retinal degeneration in dark-reared Pde6brd10 mice. Methods Postnatal day 23 (P23) phosphodiesterase (PDE) mutant (Pde6brd10) mice, P23 wild-type (WT) mice were continuously dark-reare...

Bruce A. Berkowitz, Robert H. Podolsky, Rida Waseem et al. · 0 citations

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