Author

Bruno Canard

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Open access Jul 2026

Design, structure-based optimization and antiviral evaluation of potent inhibitors for the macrodomain Mac1 of SARS-CoV-2

A complete structure-activity relationship of Mac1 of SARS-CoV-2, that was used to design potent nucleotide inhibitors, were reported, which were developed into membrane-permeable, non-toxic prodrugs, which strongly suppress viral replication.

Maximilian Sandmann, Sahra Tajdar, Simon Sander et al. · Nature Communications · 0 citations