Pulmonary tuberculosis (TB), caused by lung infection with Mycobacterium tuberculosis (Mtb), often manifests both alveolar pneumonia and aggregation of immune cells containing Mtb, termed granulomas, within the same lung. Here, we integrate spatial transcriptomics, single-cell RNA sequencing, high-resolution imaging, a...
Rosane M. B. Teles, Chaouki Benabdessalem, Jonathan Perrie et al.· Nature Communications· 0 citations
RATIONALE
Tuberculosis vaccines aim to elicit protective immunity, with IFNγ-producing CD4⁺ T cells considered central mediators of host defense. In murine models, IFNγ activates macrophages to induce inducible nitric oxide synthase (iNOS), resulting in nitric oxide-dependent control of Mycobacterium tuberculosis (Mtb)...
Fabian Stei, Erin F McCaffrey, Björn Zessin et al.· American Journal of Respirat...· 0 citations
The utility of ML-assisted evolution for engineering Rubisco with improved carboxylation efficiency and potential for enhancing crop productivity is demonstrated.
Julie L. McDonald, Jiachen Lin, Yunlong Zhao et al.· bioRxiv· 0 citations
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