Author

Bryan P. Marzullo

3 papers indexed here

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Open access Sep 2026

Tissue-wide metabolic buffering confers resilience to mitochondrial dysfunction

Mitochondria and oxidative phosphorylation (OxPhos) are essential for cellular homeostasis. However, the phenotypes caused by mitochondrial dysfunction often display remarkable tissue-specificity. What determines the susceptibility of individual cells to metabolic or mitochondrial defects in a complex in vivo tissue co...

S. Petridi, Abhilesh Dhawanjewar, Dnyanesh Dubal et al. · bioRxiv · 0 citations

Open access Sep 2026

NRF2 activation is required for chemotherapy resistance acquisition in medulloblastoma via metabolic and redox adaptation

This study explores the pivotal role of NRF2 signaling in conferring resistance to chemotherapy and ferroptosis in medulloblastoma (MB), a highly malignant pediatric brain tumor. Using newly developed in vitro models of MB cells, resistant to standard chemotherapeutics (vincistine, etoposide, cisplatin, and cyclophosph...

Lorenzo Manfreda, Fatlum Rruga, Arianna Zanolli et al. · Redox Biology · 1 citation

Open access Aug 2026

76 Metabolic Heterogeneity in Brain Tumours: Distinguishing Brain Metastases from Glioblastomas

Brain metastases account for nearly 20% of cancer-related deaths and have a five-year survival rate of 2.4%, most commonly arising from breast and lung cancers. Despite therapeutic advances, prognosis remains poor, highlighting the need for novel treatment strategies. Metabolic reprogramming is a hallmark of canc...

Ishana Rajgopal, Bryan P. Marzullo, Sana Manan et al. · Neuro-Oncology · 0 citations