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Bryon D. Johnson

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Open access Jul 2026

CAR-T with ICOS costimulation lacks therapeutic efficacy in patients due to strong trogocytosis and failure of expansion 2261203

The ICOS domain promotes trogocytosis and fratricide, explaining the poor persistence and function of ICOS CAR-T cells observed in this trial and raise significant caution for using CAR constructs that rely on ICOS for CAR activation.

Yongxia Wu, Allison Pugel, Katie A. Palen et al. · Journal of Immunology · 0 citations