Bushra Amer

T cells in type 1 diabetes: mechanisms of β-cell autoimmunity, innate-adaptive immune crosstalk, and translational immunotherapy

Type 1 diabetes (T1D) is an autoimmune disease in which immune responses drive the destruction of insulin-producing pancreatic β-cells, ultimately resulting in lifelong insulin dependence. Although T cells are central mediators of β-cell autoimmunity, growing evidence shows that innate immune cells, including dendrit...