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Byron Shue

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Oct 2026

Viral deISGylation holds the key to the metabolic kingdom.

The interferon-induced modification of cellular and viral proteins by ISG15 inhibits viral infection and is reversed by virus-encoded deISGylases, but the broad physiological impacts of this host-pathogen clash remain unclear. In this issue of Immunity, Zhu et al. reveal that ISG15 modification broadly restricts key me...

Byron Shue, Sonja M. Best · 0 citations

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