Author

Byung-Jun Yoon

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Open access Aug 2026

Optimizing protein design through uncertainty-weighted steering of protein language models

PROSOUNDS (PROtein Sequence Optimization through UNcertainty-weighteD Steering), a PLM-based protein design framework that integrates uncertainty quantification into the activation steering logic enables robust protein optimization through precise mutational design even in the absence of ground-truth labels.

Alif Bin Abdul Qayyum, Ying-Tong Zhou, Xiaoning Qian et al. · Bioinformatics · 0 citations

Jul 2026

When Do Multi-Agent Systems Help? An Information Bottleneck Perspective

This study shows that multi-agent design is fundamentally an information-bottleneck optimization problem, and explains when bounded inter-agent communication helps or hurts, and observes that MAS consistently helps when relays are near-sufficient, especially for weaker models.

Wendi Yu, Lianhao Zhou, Xiangjue Dong et al. · arXiv.org · 0 citations