C. A. Droppelmann

ARPP21 defines a TDP-43-independent aggregation pathway in amyotrophic lateral sclerosis

Currently, pathological inclusions of ubiquitinated TDP-43 are considered central to the pathogenesis of amyotrophic lateral sclerosis (ALS). However, this view has yielded sparse attention to covert alternative pathways of aggregation in the disease. Here, we identified a pathological axis independent of TDP-43 led by...