C. A. Schiffer

Nitrile-Based Inhibitors Targeting both SARS-CoV‑2 Main Protease and Human Cathepsin L.

The rational design and synthesis of dual Mpro/CatL inhibitors derived from the previously reported leads SM141 and SM142 are described, identifying multiple dual-target inhibitors with nanomolar potency against both Mpro and CatL and potent antiviral activity as well as selective Mpro inhibitors with strong enzymatic...