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Author

C. Appleton

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Open access Sep 2026

Acute TGFα drives OA-associated transcriptional and metabolic remodelling in primary chondrocytes

Objectives Articular cartilage degeneration is a hallmark of osteoarthritis (OA); however, underlying molecular mechanisms remain poorly understood. Transforming growth factor alpha (TGFα) and chondrocyte metabolism have been independently implicated in OA pathogenesis; in this study, we investigated whether TGFα affec...

Emily L. White, E. Day, C. Appleton et al. · 0 citations

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