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C. Arguello

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Open access Sep 2025

Structural basis for target discrimination and activation by Cas13d

The mechanisms of nuclease activation are explored by solving seven ternary cryo-electron mi-croscopy structures of wild-type Cas13d in complex with matched and mismatched targets and an active site loop in the HEPN domains that regulates substrate accessibility is identified.

Chia-Wei Chou, Selma Sinan, Hung-Che Kuo et al. · 0 citations