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C. Bandi

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Open access Jul 2026

Chemical Rescue Serves as a Predictive Proxy for Glycosynthase Activity on Glycosidic Bonds via a Shared Glycosyl Oxocarbenium Transition State

It is demonstrated that chemical rescue—the azide-mediated restoration of hydrolytic activity in nucleophile-deficient mutants—serves as a predictive, high-throughput proxy for glycosynthase activity as well as a structural and thermodynamic rationale for using CR to select for transition-state-stabilizing mutations.

Mohit Kumar, C. Bandi, Sri Vidya Vyjayanthi Tallavajhula et al. · 0 citations
Open access Aug 2026

Programmable protein degraders enable selective knockdown of pathogenic β-catenin subpopulations in vitro and in vivo

Aberrant activation of Wnt signaling results in unregulated accumulation of cytosolic β-catenin, which subsequently enters the nucleus and promotes transcription of genes that contribute to cellular proliferation and malignancy. Here, we sought to eliminate pathogenic β-catenin from the cytosol using designer ubiquibod...

Tianzheng Ye, A. Alamgir, C. Robertus et al. · 0 citations

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