In this study, we present the largest rare coding variant association study of schizophrenia to date, with 87,959 schizophrenia cases and 150,587 controls. We identify 16 genes at exome-wide significance: SETD1A, ZMYM2, HERC1, RB1CC1, SCAF1, XPO7, SP4, FYN, PPP3CA, CUL1, HDAC9, JARID2, ATP9A, PTK2, STAG1, and SCN2A, an...
J. Sealock, C. Dowd, Calwing Liao et al.· bioRxiv· 1 citation
Childhood maltreatment shapes brain development in ways that vary by adversity type, developmental timing, and genetic vulnerability to psychiatric illness-a heterogeneity that conventional approaches capture poorly. We contend that normative modeling, multivariate methods, and polygenic risk scores offer complementary...
Haley R. Wang, C. Bearden, T. C. Ho· Trends in Cognitive Sciences· 0 citations
Abstract Background 22q11.2 deletion syndrome (22q11DS) is strongly associated with aberrant neurodevelopment, including decreased cognitive functioning and schizophrenia spectrum disorders (SSDs). While the different core domains of IQ have distinct clinical ramifications, their collective profile has not been well-ch...
A. Fiksinski, Rielle Wierenga, D. McDonald-McGinn et al.· Psychological Medicine· 0 citations
SIB in CHR-P individuals reflects a multidimensional clinical profile primarily outside of core psychosis-risk symptoms, and overall subthreshold psychotic symptoms across the SIB spectrum indicate increasing overall subthreshold psychotic symptoms across the SIB spectrum.
S. Damiani, M. Orlandi, U. Provenzani et al.· Acta Psychiatrica Scandinavi...· 0 citations
A relationship between sleep disturbance and suicidal ideation/attempts in CHR is supported, with participants who had lifetime ideation and attempts experiencing more sleep disturbance than those with no ideation or attempts.
H. Wastler, Aubrey M. Moe, Alexandra M Blouin et al.· Schizophrenia Bulletin Open· 0 citations
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