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C. Bearden

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Open access Sep 2026

Analysis of Rare Coding Variation Identifies New Genetic Contributors to Schizophrenia

In this study, we present the largest rare coding variant association study of schizophrenia to date, with 87,959 schizophrenia cases and 150,587 controls. We identify 16 genes at exome-wide significance: SETD1A, ZMYM2, HERC1, RB1CC1, SCAF1, XPO7, SP4, FYN, PPP3CA, CUL1, HDAC9, JARID2, ATP9A, PTK2, STAG1, and SCN2A, an...

J. Sealock, C. Dowd, Calwing Liao et al. · 1 citation
Open access Oct 2026

Childhood maltreatment and the developing brain: toward individualized models of psychiatric risk.

Childhood maltreatment shapes brain development in ways that vary by adversity type, developmental timing, and genetic vulnerability to psychiatric illness-a heterogeneity that conventional approaches capture poorly. We contend that normative modeling, multivariate methods, and polygenic risk scores offer complementary...

Haley R. Wang, C. Bearden, T. C. Ho · 0 citations
Open access Sep 2026

The uneven landscape of cognitive domains in 22q11.2 deletion syndrome: A large consortium study

Abstract Background 22q11.2 deletion syndrome (22q11DS) is strongly associated with aberrant neurodevelopment, including decreased cognitive functioning and schizophrenia spectrum disorders (SSDs). While the different core domains of IQ have distinct clinical ramifications, their collective profile has not been well-ch...

A. Fiksinski, Rielle Wierenga, D. McDonald-McGinn et al. · 0 citations
Open access Sep 2026

Unraveling Suicidal Ideation and Behaviors in a Global Cohort of Individuals at Clinical High-Risk for Psychosis: Multivariable Correlates and Subthreshold Psychotic Symptoms.

SIB in CHR-P individuals reflects a multidimensional clinical profile primarily outside of core psychosis-risk symptoms, and overall subthreshold psychotic symptoms across the SIB spectrum indicate increasing overall subthreshold psychotic symptoms across the SIB spectrum.

S. Damiani, M. Orlandi, U. Provenzani et al. · 0 citations
Open access Jul 2026

Relationship among Sleep Disturbance, Stress, and Suicidal Ideation in Clinical High Risk for Psychosis

A relationship between sleep disturbance and suicidal ideation/attempts in CHR is supported, with participants who had lifetime ideation and attempts experiencing more sleep disturbance than those with no ideation or attempts.

H. Wastler, Aubrey M. Moe, Alexandra M Blouin et al. · 0 citations

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