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Author

C. Benoist

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Open access Sep 2026

A Gene-Program Architecture of Mouse T cells

We present a gene-program framework for resolving mouse T cell heterogeneity across the immgenT atlas. On ∼800,000 T cells spanning lineages, organs, and immune challenges, we defined 200 reproducible gene programs, discovered by empirical Bayes matrix factorization approach and validated through a new deep learning ap...

Ziang Zhang, Tian-Ze Wang, Siba Smarak Panigrahi et al. · 0 citations
Jul 2026

Mapping the chromatin landscape of the mouse immune system with low-input automated CUT&RUN 2260000

Understanding how immune cells develop and function requires insight into the epigenomic mechanisms that regulate gene expression. While many genomic studies focus on transcriptional outputs, changes in the chromatin landscape play a central role in shaping lineage commitment. The mammalian immune system is compo...

Aaron J. Alcala, M. Marunde, C. L. Windham et al. · 0 citations

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