Open access
Sep 2026
Coenzyme A activates TLR4 and enhances alternative macrophage activation in line with MyD88 agonism.
Metabolites and metabolic cofactors can shape the innate immune response, though the pathways by which these molecules adjust inflammation remain incompletely understood. Here we show that the metabolic cofactor coenzyme A (CoA) enhances IL-4 driven alternative macrophage activation [M(IL-4)] in vitro and in vivo. Unex...
Anthony E. Jones, Amy Rios, Neira Ibrahimovic et al.
· EMBO Reports · 0 citations