HLA-DQ Allele Combinations and Antibody Profiles in Children With Type 1 Diabetes: A Retrospective Study
Introduction: Type 1 diabetes (T1D) is an autoimmune disease where T cells gradually destroy pancreatic beta cells. The strongest genetic factors influencing T1D susceptibility are HLA-DQ haplotypes, which affect the variety of autoantigens presented to T cells. Islet autoantibodies, such as insulin (IAA), glutamic aci...