The observed genetic correlations are consistent with shared genetic liability between DED and chronic pain, autoimmune, and psychiatric traits, but do not establish causal direction.
Bryan R. Gorman, Jaxon J. Huang, Peter B. Barr et al.· EBioMedicine· 0 citations
Common brain disorders impose a substantial health burden, but localizing their genetic risk in the brain remains challenging1. Although genome-wide association studies have identified numerous loci associated with neuropsychiatric and neurodegenerative disorders, many of these loci lie in non-coding regions that influ...
S. Venkatesh, Roman Kosoy, Zhen-Yi Wu et al.· Nature· 6 citations
Bipolar disorder’s genetic architecture appears hierarchical—a general liability resolving into dimensions of course and comorbidity, beyond subtypes, beyond subtypes.
Tracey van der Veen, M. Tesfaye, J. M. K. Yang et al.· Research Square· 0 citations
These findings demonstrate that leveraging whole-genome sequencing in large-scale biobanks enables the identification of rare protein-coding variants, genes, and gene sets associated with AML.
S. Vieno, M. Singh, S. Kramer et al.· medRxiv· 0 citations
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