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Author

C. Chen

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Open access Sep 2026

scTransMIL bridges patient-level disease states and single-cell transcriptomics for cancer screening and heterogeneity inference

Single-cell sequencing offers profound insights into tumor complexity. However, reliably linking individual cellular profiles to overall sample-level phenotypes remains computationally challenging, particularly when cell-specific annotations are absent. This disconnect limits the technology’s utility in studying underl...

Zhen-Chao Tang, Fang Wang, Fan Yang et al. · 2 citations
Aug 2026

DiConSite: A Unified Topology-Adaptive Architecture for Protein Binding Site Prediction Across Ligand Modalities.

By combining protein language model embeddings with topology-adaptive geometric reasoning, DiConSite offers a reusable framework for residue-level protein interaction analysis and achieves consistently strong and often best-performing results, while improving robustness to structural uncertainty and cross-modal variati...

Shou-Zhi Chen, Zhen-Chao Tang, Lin-Lin You et al. · 1 citation

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