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Open access Aug 2026

Towards Interpretable AI Second Opinions: Foundation Model Heatmaps in Radiology

AI-assisted diagnostic tools typically act as a "second opinion," providing radiologists with a discrete prediction or probability score that can be consulted alongside clinical context. This treats AI as an independent advisor rather than a collaborative partner, leaving its reasoning largely opaque. We explore a complementary approach grounded in human-AI collaboration through visual interpretability. Specifically, we investigate (1) radiologist performance when diagnosing chest X-rays from images alone, and (2) whether deep learning-generated heatmaps can support radiologists during this diagnostic process, rather than merely validating a final answer. We developed an interactive application that enables readers to engage directly with model-generated heatmaps as they form their diagnoses, and conducted a user study to evaluate how this influences diagnostic behaviour and accuracy. Our findings offer new insights into integrating interpretable, spatially grounded AI feedback into radiologist workflows. Code, datasets, and the application can be found at https://github.com/eedack01/heatmap_assisted_diagnosis.

E. Dack, C. Dai, H. Hoppe et al. · 0 citations
Preprint Jul 2026

EviBack: Search-Agent Reinforcement Learning via Evidence-Constrained Teacher Backoff

Reinforcement learning enables Agentic RAG systems to learn multi-turn search from verifiable outcome rewards, but all- zero rollout groups provide no comparative signal and may hide useful search behavior. We present EviBack, an evidence- constrained Teacher backoff that supplies auxiliary super- vision to such groups while preserving verifiable Actor re- wards. It separates evidence assessment from answer refine- ment, preventing reference answers from overriding evidence- insufficiency judgments. A fully automated, end-to-end GPT- 5.5-assisted APE pipeline starts from a manually authored single-prompt dual-task Teacher, automatically partitions and labels rollout data, and performs ablation, task decomposition, evaluation, and selection to produce a gated two-stage Teacher. Compared with the manual design, the resulting Teacher im- proves downstream F1 and valid-answer rate while reduc- ing search, duplicate queries, and forced termination. Across seven open-domain QA benchmarks and three Qwen3 scales, EviBack improves F1 over Search-R1 and raises both single- and multi-hop macro F1. We guarantee that the code will be made publicly available at a later stage.

Xiao Ma, Zhiquan Hu, Yi Wei et al. · 0 citations