Pancreatic β-cell mitogenic regeneration in type 1 diabetes: A preclinical review.
Type 1 diabetes (T1D) is caused by autoimmune destruction of insulin-producing pancreatic β-cells, resulting in hyperglycaemia. The first-line treatment for symptomatic T1D is exogenous insulin replacement to maintain glycaemic control. Islet transplant therapy is available to a small number of individuals, and stem ce...