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Review Sep 2026

Abstract IA03: Immune Related Toxicities Associated with Immunotherapies

Chimeric antigen receptor T-cell (CART) therapy has revolutionized care for many pediatric cancers, especially relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL). Although CART are highly effective, they can induce severe toxicities. The most common severe adverse events associated with CART are cytok...

C. Diorio · 0 citations
Sep 2026

Multimodal analysis of CD38 in T-cell Acute Lymphoblastic Leukemia Identifies Combinatorial Therapeutic Strategies.

Outcomes for pediatric patients with refractory or relapsed T-cell acute lymphoblastic leukemia (T-ALL) are poor, underscoring the need for improved therapeutic strategies. CD38, a type II transmembrane glycoprotein, is a promising target in T-ALL, with clinical trials evaluating CD38-targeting immunotherapies in front...

R. Shraim, Gong-Ping Shi, Yi-Zhen Li et al. · 0 citations

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