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Open access Oct 2026

Control of Helix Screw-Sense Preference in Dynamic Foldamers of meso Symmetry Built From Chiral Monomeric Units.

Meso oligoureas are dynamic hydrogen-bonded foldamers capable of reversible helix polarity inversion but have so far been limited to symmetrical meso-cyclohexane-1,2-diamine monomeric units, limiting both sequence diversity and structural modification. Here, we report the synthesis and characterization of meso and "nea...

N. Gupta, Mégane Bornerie, Bo Li et al. · 0 citations
Open access Aug 2026

A protein–foldamer supramolecular synthon for self-assembled hybrid architectures

Constructing artificial assemblies that combine proteins and synthetic ligands has been hampered by the lack of protein–ligand interfaces that are sufficiently large and organized to enable precise structural control. Here ribosome display selection is used to identify a protein that binds a helical aromatic foldamer b...

Johannes Sigl, Vasily Morozov, Ling-Fei Wang et al. · 1 citation

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