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Author

C. Engelman

2 papers indexed here

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Sep 2026

Multi-omics integration of transcriptomics and metabolomics with machine learning uncovers novel risk factors for Alzheimer's disease.

BackgroundAlzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline, memory impairment, and functional deterioration. Its complex pathogenesis involves amyloid plaques, tau tangles, neuroinflammation, synaptic dysfunction, and interacting genetic, environmental, and lifestyle factors....

Jerome J. Choi, C. Engelman, Tianyuan Lu · 0 citations
Open access Sep 2026

Plasma P-tau217, APOE Genotype, and the Timing of Cognitive Impairment in individuals Across Diverse Racial and Ethnic Groups: A Pooled Analysis of Prospective Cohort Studies

ABSTRACT/SUMMARY Background: Plasma phosphorylated tau217 (P-tau217), a biomarker of Alzheimer’s disease (AD), can increase before overt symptoms. However, individuals with similar P-tau217 levels but different genetic backgrounds might differ in their risk or timing of cognitive decline. We aimed to determine whether...

Yue-Xuan Xu, T. I. Gunasekaran, Yian Gu et al. · 0 citations

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