BackgroundAlzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline, memory impairment, and functional deterioration. Its complex pathogenesis involves amyloid plaques, tau tangles, neuroinflammation, synaptic dysfunction, and interacting genetic, environmental, and lifestyle factors....
Jerome J. Choi, C. Engelman, Tianyuan Lu· Journal of Alzheimer's Disea...· 0 citations
ABSTRACT/SUMMARY Background: Plasma phosphorylated tau217 (P-tau217), a biomarker of Alzheimer’s disease (AD), can increase before overt symptoms. However, individuals with similar P-tau217 levels but different genetic backgrounds might differ in their risk or timing of cognitive decline. We aimed to determine whether...
Yue-Xuan Xu, T. I. Gunasekaran, Yian Gu et al.· Lancet Neurology· 0 citations
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