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Open access Aug 2026

ATP13A4 gates extracellular polyamine levels to control excitatory synaptogenesis

Polyamines, such as spermidine, are essential regulators of brain development, yet how cells control their uptake and extracellular levels remains unclear. Here we show that ATP13A4, a transport protein enriched in glia and prominently expressed in astrocytes, governs brain polyamine balance. Using biochemical, cellula...

S. van Veen, Emily Meeus, D. Irala et al. · 1 citation
Review Jul 2026

Glia orchestrate neural circuit development.

Over the past ∼25 years, our understanding of neural circuit development in the central nervous system has shifted. Once considered passive supporters, glial cells, namely, astrocytes, oligodendrocyte lineage cells, and microglia, are increasingly recognized as active regulators of developmental circuit formation and m...

K. Sakers, Patrick W. Sheehan, Wendy Xin et al. · 0 citations

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