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Review Open access Aug 2026

Chemical Biology Tools for the O-GlcNAc Modification: Determining Systems-Level Functions and Druggability

How can a single monosaccharide control nearly every human cellular feature? This question has hounded the O-GlcNAc field since 1984. Despite identifying thousands of O-GlcNAc proteins, high-throughput datasets have only deepened the mystery. This Current Opinion highlights chemical biology tools (current as of 2023–20...

C. Fehl · 0 citations

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