Chemical Biology Tools for the O-GlcNAc Modification: Determining Systems-Level Functions and Druggability
How can a single monosaccharide control nearly every human cellular feature? This question has hounded the O-GlcNAc field since 1984. Despite identifying thousands of O-GlcNAc proteins, high-throughput datasets have only deepened the mystery. This Current Opinion highlights chemical biology tools (current as of 2023–20...