Author

C. Goldman

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Review Open access Sep 2026

IL-15 trans-presentation at the innate-adaptive interface: mechanisms and translation in cancer immunotherapy

ABSTRACT Durable antitumor immunity requires innate activation, antigen presentation, lymphocyte priming, trafficking, and effector function. In immunologically cold tumors, deficient dendritic-cell and natural killer (NK)-cell activation limits the transition from tumor-antigen recognition to CD8 T-cell immunity. Inte...

C. Goldman · Oncoimmunology · 0 citations

Open access Sep 2026

Systemic Transcriptional Responses to Clinical Vaccine Formulations and Live-Attenuated Vaccination: Comparative Kinetics and Hypotheses for Therapeutic Cancer Vaccine Monitoring

Background/Objectives: Therapeutic cancer vaccination requires innate sensing, antigen presentation, lymphocyte priming, tumor access, cytotoxicity, and persistence. Prophylactic studies cannot demonstrate these antitumor functions but can compare systemic formulation responses. We tested whether blood transcription ex...

C. Goldman · Vaccines · 0 citations

Review Open access Aug 2026

Integrated Immunotherapy Target Atlas for Ewing Sarcoma

Abstract Background/Aim: Ewing sarcoma is a fusion-driven malignancy with low tumor mutational burden, making recurrent tumor-associated antigens with favorable tumor-to-normal contrast central to immunotherapy development. We converted the Deng et al.-defined 32-gene Ewing Sarcoma Specific Signature (ESS32) into a pra...

C. Goldman · Cancer Genomics & Proteomics · 0 citations