Author

C. Gouttefangeas

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Open access Aug 2026

A targetable dependency on nonsense-mediated decay for cellular homeostasis and immune control in small cell lung cancer

This work identified that NMD inhibition boosted neoantigen expression and presentation by tumor cells and increased T cell recognition, thus enhancing overall tumor immunogenicity and further improving immunotherapy efficacy in vivo, uncovering a novel TMB-dependent tractable vulnerability for this devastating disease...

Lucia A. Torres-Fernández, V. Boehm, Joel Kaufmann et al. · Molecular Cancer · 0 citations

Open access Jul 2026

Chemically synthesized, non-capped and non-polyadenylated peptide-coding RNA efficiently induces antigen-specific CD8+ T cells.

This work shows that short, chemically synthesized RNA oligonucleotides lacking some or all of these features are efficiently translated when they encode epitopes recognized by CD8+ T cells and introduces the possibility that defective or supposedly non-coding RNA may encode human and murine major histocompatibility co...

Julia Frei, D. Eisel, N. Jarzębska et al. · Nature Biomedical Engineerin... · 1 citation