C. Herold-Mende

31 CD44-Gal9 Interaction between IDH1-mutant Grade 4 Astrocytoma and Microglia Promotes Invasion and Proliferation of Tumor Cells

CD44-Gal9 signaling is identified as a clinically relevant axis promoting tumor invasiveness and immune evasion in IDH1-mutant astrocytomas andTherapeutic inhibition of this interaction may represent a promising strategy to simultaneously attenuate tumor aggressiveness and reprogram the tumor microenvironment.