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Open access Sep 2026

Patterns, predictors and outcomes of the joint trajectories of positive and negative symptoms in patients with early psychosis: 12-year follow-up of the randomized controlled trial on extended early intervention.

BACKGROUND Positive and negative symptoms are considered core features of psychotic disorders. However, no study has identified joint trajectories of positive and negative symptoms in early psychosis with long-term follow-up. METHOD We conducted 12-year follow-up of a randomized-controlled trial on extended early int...

Chris Chit Sze Fung, Ryan Sai-Ting Chu, Natalie Wing Tung Chu et al. · 0 citations
Open access Sep 2026

Early-stage trajectories of social-occupational functioning and long-term functional outcome prediction in early psychosis: A 12-year follow-up of the randomized controlled trial on extended early intervention

Abstract Background Functional impairment in psychosis often persists despite symptomatic remission. There is a paucity of research examining early-course psychosocial functioning trajectories, and none has been conducted to examine relationship between the trajectories and prospective long-term functional outcomes in...

Natalie Wing Tung Chu, Ryan Sai-Ting Chu, Chris Chit Sze Fung et al. · 0 citations
Open access Sep 2026

Unraveling Suicidal Ideation and Behaviors in a Global Cohort of Individuals at Clinical High-Risk for Psychosis: Multivariable Correlates and Subthreshold Psychotic Symptoms.

INTRODUCTION Suicidal ideation and behaviors (SIB) are common among individuals at clinical high risk for psychosis (CHR-P), but their relationship with the overall clinical profile remains unclear. This study aimed to identify sociodemographic/clinical factors associated with SIB in CHR-P individuals and to examine wh...

S. Damiani, M. Orlandi, U. Provenzani et al. · 0 citations

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