Background: Home mechanical ventilation (HMV), including noninvasive ventilation (NIV) and invasive ventilation (IV), is increasingly used in people with amyotrophic lateral sclerosis (pwALS), but its impact on end-of-life care remains unclear. Objective: To examine whether ventilation pathway (NIV or IV) influences sy...
Микаэль Дальквист, K. Ersson, Stefan S. O. Bergström et al.· Amyotrophic Lateral Sclerosi...· 0 citations
Abstract Plasma cardiac troponin T (cTnT) is widely used as a marker of myocardial injury, yet recent studies suggest elevations in amyotrophic lateral sclerosis (ALS). Whether these elevations reflect disease-associated skeletal muscle remodelling remains unresolved. In this translational study, we analysed longitudin...
L. Öijerstedt, Jia-Ning Lin, Aditya Singh et al.· Brain Communications· 0 citations
Plasma and cerebrospinal fluid (CSF) protein biomarkers in amyotrophic lateral sclerosis (ALS) may provide insight into disease mechanisms and yield clinically useful biomarkers.
Lu Pan, C. Hou, Christina Seitz et al.· European Journal of Neurolog...· 0 citations
Cell-type enrichment analysis indicating a broad cellular origin of the circulating proteome, with contributions from nervous system cells, vascular cells, immune cells, and muscle cells, highlights the potential of plasma proteomics for clinically meaningful patient stratification in ALS.
I. Aksoylu, L. Azizi, L. OÌijerstedt et al.· medRxiv· 0 citations
While NfL reflects disease aggressiveness, hs-cTnT aligns with disease phase and clinical phenotype, supporting its use as a complementary biomarker for ALS characterisation and monitoring.
Julia Sellin, Linn Öijerstedt, Janina von der Gablentz et al.· Journal of Neurology· 0 citations
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