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Review Open access Sep 2026

Connective tissue disorders and cardiac arrhythmias: genetic pathways, mechanistic bridges, and clinical implications

Background Connective tissue disorders (CTDs) such as Marfan syndrome, Loeys-Dietz syndrome, and Ehlers-Danlos syndromes are traditionally defined by vascular fragility and aortic complications. Increasing evidence, however, demonstrates that CTDs also predispose to atrial and ventricular arrhythmias, often independent...

L. Dreher, Hussein Abdul Nabi, Ramzi Ibrahim et al. · 0 citations
Review Oct 2026

Ventricular Arrhythmias in Marfan Syndrome: Prevalence and Clinical Correlates in a Multicenter Cohort.

BACKGROUND Ventricular arrhythmias are increasingly recognized in Marfan syndrome, but associated clinical and structural features remain incompletely defined. METHODS We performed a retrospective multicenter cohort study of 783 adults with confirmed Marfan syndrome at 3 Mayo Clinic sites. Clinical, arrhythmic, echoc...

L. Dreher, Hussein Abdul Nabi, C. Kanaan et al. · 0 citations

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