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Findings identify cell-intrinsic C3 as a suppressor of IFN-β production in human macrophages, highlighting the importance of the cell-intrinsic complement system in fine-tuning inflammatory responses to pathogens.
It is shown that the CD46 signaling domain cytoplasmic tail 1 (CYT-1) engages the transcription factor Sp1 in human CD4 T cells to dynamically modulate Sp1-DNA interactions, defining a human-specific transcriptional mechanism linking complement signaling to metabolic adaptation, apoptosis regulation, and antiviral defe...
A systematic catalog of eRNAs in human adaptive immune cells is defined and a distal transcribed enhancer is identified that fine-tunes KRAS signaling in Tfh cells to support effective vaccine responses, establishing eRNAs as noncoding regulators of T cell circuits controlling antibody production.
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