Author

C. L. Moore

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Review Open access Oct 2026

Regulatory T cell function and engineering for next generation cell therapies

Regulatory T cells (Tregs) are essential for immune tolerance and tissue homeostasis. Their dysfunction contributes to a broad range of autoimmune, inflammatory, and degenerative diseases, motivating interest in Treg-based therapies. Clinical translation has been constrained by limited stability, persistence, and funct...

N. Zammit, Martina Sassone-Corsi, P. Zarin et al. · Frontiers in Immunology · 0 citations

Open access Aug 2026

A synthetic NKG2A engager enables long-term persistence of HLA-deficient allogeneic engineered Tregs.

An improved NKG2A engager is reported to selectively inhibit NKG2A⁺ NK cells while avoiding activation of NKG2C⁺ subsets, thereby overcoming a key limitation of the natural ligand HLA-E.

Tingxi Guo, Kaya Epstein, M. Hoover et al. · EMBO Molecular Medicine · 0 citations