Discovery of the order ‘Quisvirales’ redefines the evolution of RNA replication and transcription in the phylum Pisuviricota
Abstract Genome replication in positive-stranded RNA (ssRNA+) viruses is mediated by cognate enzymes, including ubiquitous RNA-dependent RNA polymerase (RdRp). In ssRNA+ viruses with multiple open reading frames (ORFs) in their genomes, replication often is accompanied by synthesis of subgenomic RNAs (transcription) fo...