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Author

C. Martino

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Open access Aug 2026

Integrated multi-omics analysis identifies microbial and metabolic signatures and drivers of CNS autoimmunity

ABSTRACT Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS), driven by genetic and environmental determinants. The gut microbiome of people with MS (pwMS) is distinct and influences disease through immunomodulatory metabolite production. Circulating metabolites are altered in pwMS, but...

T. Montgomery, Emily A. Nelson, Lauren A. Downs et al. · 0 citations
Open access Jul 2026

Integrated multi-omics analysis identifies microbial and metabolic signatures and drivers of CNS autoimmunity 2305382

Dietary response is modulated by gut microbiome composition and that integrated microbiomic-metabolomic analyses can predict drivers of disease worsening in MS, indicate that dietary response is modulated by gut microbiome composition.

T. Montgomery, Emily A. Nelson, Lauren A. Downs et al. · 0 citations
Open access Aug 2026

Joint-RPCA: domain-aware multi-omics integration for systems microbiology.

Joint Robust Principal Component Analysis (Joint-RPCA), a method designed with these statistical properties in mind and broadly applicable to multi-omics settings with similar challenges, reveals replicable and interpretable multi-omic patterns.

Bianca Cordazzo Vargas, C. Martino, A. Dilmore et al. · 1 citation

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