Author

C. Mathieu

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Open access Sep 2026

Exploratory Analysis of Continuous Glucose Monitoring Patterns in First-Degree Relatives with Dysglycemia at Risk of Progression to Stage 3 Type 1 Diabetes.

INTRODUCTION Continuous glucose monitoring (CGM) can characterize subtle glucose changes in early-stage type 1 diabetes (T1D). We assessed whether CGM metrics predict Stage 3 T1D in first-degree relatives (FDRs) with positive islet autoantibodies (IAbs) and dysglycemia participating in INNODIA. METHODS We analyzed IA...

Olivier G. Pollé, T. Battelino, Pieter-Jan Martens et al. · Diabetes Technology & Therap... · 0 citations

Review Open access Aug 2026

Citrullination and Deamidation in Type 1 Diabetes: Linking Beta Cell Stress to Neoantigen‐Driven Autoimmunity

Citrullination and deamidation are post‐translational modifications (PTMs) increasingly recognized as important contributors to neoepitope formation in type 1 diabetes (T1D). Under inflammatory and endoplasmic reticulum stress conditions, beta cells activate calcium‐dependent peptidylarginine deiminase and transglutami...

A. Callebaut, Ylke Bruggeman, C. Mathieu et al. · Immunological Reviews · 0 citations

Review Jul 2026

Insulin resistance and type 2 diabetes as allostatic responses to chronic nutrient excess.

Obesity-related type 2 diabetes (T2D) is currently defined by insulin resistance and impaired insulin secretion. Sulfonylureas, thiazolinediones, and insulin are effective at lowering glycemia yet have not consistently translated into improved long-term outcomes. In contrast, recent interventions often produce metaboli...

M. Prentki, Christopher J. Nolan, David E. James et al. · Cell Metabolism · 0 citations