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Author

C. Morrissey

3 papers indexed here

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Open access Aug 2026

Deep learning-based histologic classifiers enable molecular subtyping of metastatic prostate cancer.

Metastatic prostate cancer is a clinically and molecularly heterogeneous disease. Under the selective pressure of androgen receptor (AR)-directed therapies, resistant phenotypes frequently emerge, posing significant diagnostic and therapeutic challenges. Neuroendocrine prostate cancer (NEPC) is a clinically important p...

Zhi-Jun Chen, Erolcan Sayar, D. Guevara et al. · 0 citations
Open access Sep 2026

Evolution and heterogeneity of lethal metastatic bladder cancer subtypes.

Histological variation is a prognostic feature of metastatic urothelial cancer1-3, but its evolutionary trajectory remains poorly defined. We developed a metastatic bladder cancer rapid autopsy programme enriched in histological subtypes4 to profile individuals with terminal disease. Here by reconstructing the evolutio...

P. Itagi, Samantha L. Schuster, Sonali Arora et al. · 0 citations
Open access Aug 2026

Combined BET bromodomain and DNMT inhibition targets critical survival pathways in transdifferentiated prostate cancer.

Lineage plasticity, or transdifferentiation, is increasingly recognized as a resistance mechanism to androgen receptor (AR) inhibition in prostate cancer. Lineage plasticity is characterized by loss of AR signaling and epithelial differentiation, along with activation of stemness-associated pathways, epithelial-mesench...

W. Storck, Diana Flores, A. Kumaraswamy et al. · 0 citations

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