Author

C. Patel

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Review Open access Oct 2026

Regulatory T cell function and engineering for next generation cell therapies

Regulatory T cells (Tregs) are essential for immune tolerance and tissue homeostasis. Their dysfunction contributes to a broad range of autoimmune, inflammatory, and degenerative diseases, motivating interest in Treg-based therapies. Clinical translation has been constrained by limited stability, persistence, and funct...

N. Zammit, Martina Sassone-Corsi, P. Zarin et al. · Frontiers in Immunology · 0 citations

Open access Jul 2026

GNTI-932: A Targeted, Scalable, and Hypoimmune Allogeneic Engineered Treg therapy for the treatment of Inflammatory Bowel Disease 2251383

GNTI-932 is a novel, hypoimmune, antigen-specific, off-the-shelf immunotherapy for restoring tolerance in IBD, designed to be scalable and affordable for widespread use.

Martina Sassone-Corsi, J. Yam, Abigail Doherty et al. · Journal of Immunology · 0 citations

Jul 2026

An allogeneic CD19 targeted Engineered Treg approach for treating B cell mediated autoimmune diseases 2260315

GNTI-350 can safely achieve a durable immune reset and may provide superior therapeutic benefit over CAR-T approaches to patients with B cell—driven autoimmune diseases.

P. Zarin, Chris B. Moore, Travis Drow et al. · Journal of Immunology · 0 citations