Sex-specific hippocampal trajectories induced by peripubertal and adult acute stress: proteomic profile, microglial alterations, neurogenic dysregulation, and depression-like behaviors
Depression is highly prevalent, and early-life adversity is an important risk factor for adult psychopathology. Although females show greater vulnerability to stress-related affective disorders, the mechanisms underlying sex-dependent stress responses remain unclear. Using a two-hit framework, we examined whether juv...