Author

C. Piperi

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Open access Aug 2026

Targeting SUV4–20H2-mediated H4K20 methylation restrains growth and migration in pediatric high-grade astrocytomas

Pediatric astrocytomas are characterized by increased molecular and clinical heterogeneity with epigenetic alterations contributing to aggressiveness and therapy resistance. The repressive histone mark H4K20 trimethylation (H4K20me3) and the methyltransferase SUV4–20H2 (KMT5C) are critical regulators of chromatin integ...

A. Giannopoulou, Elisavet Kosma, Dimitrios S. Kanakoglou et al. · Neurotherapeutics · 0 citations

Review Open access Aug 2026

Polycomb Repressive Complex 2 (PRC2): A Context-Dependent Epigenetic Regulator of Brain Aging

Structural and functional aspects of PRC2 are described, with emphasis on the potential of this epigenetic context-dependent regulator to integrate developmental, environmental and aging-related signals, to shape the transcriptional landscape of aging brain.

Maria A Katsianou, E. Vetsika, Mariam Markouli et al. · Biomolecules · 1 citation

Review Aug 2026

Epigenetic Drift and LINE-1 Activation in Aging Brain: Implications for Neurodegenerative Disease.

Brain aging and age-associated neurological diseases, such as Alzheimer's Disease (AD), Parkinson's Disease (PD), and Amyotrophic Lateral Sclerosis (ALS), are largely attributed to epigenetic drift which is characterized by the gradual accumulation of alterations in neural cell methylation patterns over time. These met...

Alkinoos A. Armoundas, C. Piperi · Mechanisms of Ageing and Dev... · 0 citations