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Open access Sep 2026

668. Serotonin, melatonin, and kynurenines: bridging neurochemical pathways in schizophrenia and beyond

Abstract Background Cognitive deficits and metabolic syndrome are highly prevalent in schizophrenia (SCZ), suggesting shared underlying biological mechanisms. Emerging evidence points to the dysregulation of tryptophan (Trp) metabolism, specifically the balance between the serotonin/melatonin (MLT) and kynurenine (Kyn)...

B. Barzon, A. Shkodra, S. Nasini et al. · 0 citations
Open access Sep 2026

683. Genomic foundations of precision treatment: polygenic risk and pleiotropy in predicting therapeutic response

Abstract Background Major depressive disorder (MDD) is the most common mental disorder and is associated with substantial functional impairment, socioeconomic costs and reduced quality of life. One third of patients presents treatment-resistant depression (TRD), a major clinical challenge that highly contributes to the...

C. Pisanu, Y. Xiong, D. Congiu et al. · 0 citations
Open access Sep 2026

443. Transcriptomic analysis reveals differential mRNA expression in bipolar disorder

This study suggests that BD patients present significant differences in gene expression patterns compared to healthy controls, and pathway analyses suggest that protein misfolding and endoplasmic reticulum alterations could be implicated in the pathophysiology of BD, while response to lithium might be related to modula...

A. Squassina, M. Manchia, C. Chillotti et al. · 0 citations

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