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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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C. Pomilio

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Open access Sep 2026

Differential Effects of Neutral Sphingomyelinase and Serine Palmitoyltransferase Inhibitors on Alzheimer’s-Like Neuropathology

Alzheimer’s disease (AD) involves progressive neurodegeneration, amyloid-β (Aβ) pathology and chronic neuroinflammation. Elevated ceramides, generated via neutral sphingomyelinase (nSMase)-mediated sphingomyelin hydrolysis or serine palmitoyltransferase (SPT)-driven de novo synthesis, amplify these processes. Here, we...

Melina P. Bellotto, Nicolás González Pérez, M. Bentivegna et al. · 0 citations

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