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Author

C. Pouton

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Open access Aug 2026

Long-read sequencing quantifies synthetic mRNA abundance, integrity and host response in vivo

Applied to lipid nanoparticle (LNP) delivered mRNA in mice, the method revealed tissue-specific delivery and degradation patterns and uncovered a critical disconnect between mRNA accumulation and protein expression across organs.

Victoria McLeod, D. Yuen, Moore Z. Chen et al. · 0 citations
Review Open access Aug 2026

Beyond PEG: Emerging Polymer Lipid Alternatives for Lipid Nanoparticle (LNP) Formulations

Overall, PEG lipid alternatives should not be viewed as simple PEG mimics, but as distinct surface‐engineering materials that create new nano‐bio interfaces and reshape LNP behavior in biological systems.

Zihnil A. I. Mazrad, Yi Ju, S. J. Kent et al. · 3 citations

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