Background: Cancer has traditionally been framed as a cell-intrinsic genetic disease and, more recently, as a disorder of the tumor microenvironment (TME). An emerging third view reframes malignancy as a systems-level neuroimmune disorder, in which neurons, glia, immune cells, and tumor cells form a continuously commun...
Agastya Mittal, C. Rawson, Jaime Tellez et al.· Neuroimmunomodulation· 0 citations
BACKGROUND
Pediatric stroke is a significant cause of long-term disability worldwide, with outcomes influenced by age, stroke subtype, and access to care. Our objective was to define the global burden of pediatric stroke by its impact on mortality and disability.
METHODS
The Global Burden of Disease study uses advanc...
C. Rawson, Lisa M. Pabst, Karol P. Budohoski et al.· Stroke· 0 citations
BBB microdisruption, particularly through FUS with microbubbles, represents a transformative platform for central nervous system gene therapy, and continued research is needed to standardize treatment protocols, characterize long-term safety, and facilitate broader clinical translation.
M. Rashad, Agastya Mittal, Srivardhan Chirasani et al.· Journal of Molecular Patholo...· 0 citations
BACKGROUND
Brain metastasis is a major contributor to morbidity in advanced cancer, with substantial variability in incidence and biological behavior across primary tumor types and molecular subtypes. Increasing evidence suggests that cerebral organotropism is driven by coordinated interactions between tumor-intrinsic...
Henry Freeman, C. Rawson, Denise Baloi et al.· Oncology· 0 citations
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