Hypertrophic cardiomyopathy (HCM) is a disease of heart muscle commonly caused by variants in genes encoding sarcomere-associated proteins. The mechanisms by which these variants lead to the phenotype are uncertain, partly because of the lack of model systems amenable to integrated translational studies. We generated Y...
Eric M. Green, C. D. del Rio, K. Shibbani et al.· JACC: Basic to Translational...· 0 citations
BACKGROUND
Atrial fibrillation (AF) is the most common arrhythmia in dilated cardiomyopathy (DCM) and is associated with adverse outcomes. However, the genetic determinants of AF risk and its prognostic significance across genotyped DCM subtypes remain unknown.
METHODS
In this observational cohort study, we analyzed...
I. Balakrishnan, A. Heymans, B. Claggett et al.· Circulation: Heart Failure· 0 citations
Unsupervised and supervised machine learning approaches distinguished HCM from dilated cardiomyopathy and accurately predicted genotype status in early-stage HCM from cell type-resolved transcriptional profiles, revealing widespread genotype-driven remodeling.
E. Adami, Yuri Kim, Sean L. Zheng et al.· Science Translational Medici...· 1 citation
TrioMix-UPD, an integrated short- and long-read sequencing framework for UPD detection and classification, is developed and established UPD as an underrecognized contributor to CHD.
Nahyun Kong, Javier Abello, Christopher J. Yoon et al.· Research Square· 0 citations
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