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C. Semple

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Open access Aug 2026

Explainable machine learning relates histological to genomic pathology

Background & Aims Haematoxylin and eosin (H&E) staining remains the diagnostic gold standard for solid cancers, including hepatocellular carcinoma, and is increasingly complemented by genomic profiling for precision medicine. Inferring genomic alterations directly from H&E images could streamline testing, but heterogen...

John Connelly, Bárbara Hernando, Juliet Luft et al. · 0 citations
Open access Aug 2026

The human RNA-DNA interactome is cell type-specific and dynamic

The RNA-DNA interactome is established as a new genome regulatory layer that defines and maintains cellular identity and behavior and is shown to be highly dynamic yet reproducibly organized in cell-type specific networks.

A. Lambolez, P. Sahlén, Wenjing Kang et al. · 1 citation

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