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C. Solinas

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Review Open access Sep 2026

AI-driven multi-omics biomarkers in precision breast cancer therapeutics: from discovery to clinical translation

Breast cancer is biologically heterogeneous, yet conventional clinical decisions rely on static, single-marker proxies (ER, PR, HER2, and Ki-67) that capture only a narrow slice of tumor biology. This mini-review argues that AI-driven multi-omics biomarkers offer a valuable shift toward systems-level, model-derived pro...

D. Stylianakis, R. Sánchez-Bayona, N. Denaro et al. · 0 citations
Review Open access Aug 2026

Isocitrate dehydrogenase (IDH) as target for anticancer therapy in brain and gastrointestinal cancers

Isocitrate dehydrogenase (IDH) enzyme system plays a central role in cellular metabolism, growth, and differentiation, and its mutations are associated with alterations of the cell cycle and production of oncometabolites, promoting tumor development. In this narrative review, we provide an overview of the current evide...

Virginia Agnetti, Alessandro Acunzo, Giulia Airò et al. · 0 citations

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