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Open access Oct 2026

A latent metabolic dysfunction phenotype integrating insulin resistance and leptin is associated with disease severity in COPD

Chronic obstructive pulmonary disease (COPD) is increasingly recognised as a systemic condition in which metabolic dysfunction may influence disease severity and exacerbation risk. The combined effects of insulin resistance and leptin dysregulation on COPD outcomes remain incompletely defined. This study evaluated...

Oana Maria Catană, Denisa Maria Mitroi, Ramona Cioboată et al. · 0 citations
Open access Sep 2026

Multidimensional Inflammatory Biomarker Profiling in COPD: A Latent Inflammatory Construct Associated with Disease Severity and Exacerbation Burden

Background/Objectives: Systemic inflammation is a widely recognised feature of chronic obstructive pulmonary disease (COPD). The combined contribution of acute-phase reactants and pro-inflammatory cytokines to disease severity and exacerbation risk remains incompletely understood. This study evaluated the associations...

Oana Maria Catană, Ramona Cioboată, D. Mitroi et al. · 0 citations

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