Open access
Aug 2026
Temporal uncoupling of radial glia lineage progression in cortical organoids
It is found that RGPs exhibit a high level of plasticity in proliferative potential in organoids rather than strict temporally stereotyped lineage progression as observed in vivo, indicating that missing non-cell-autonomous niche cues are essential for faithful temporal control of cortical lineage progression.
Melissa Stouffer, Osvaldo A. Miranda, F. Pauler et al.
· Nature · 2 citations